(Heb. ‘ezob; LXX. hyssopos), first mentioned in Ex. 12:22 in connection with the institution of the Passover. We find it afterwards mentioned in Lev. 14:4, 6, 52; Num. 19:6, 18; Heb. 9:19. It is spoken of as a plant “springing out of the wall” (1 Kings 4:33). Many conjectures have been formed as to what this plant really was. Some contend that it was a species of marjoram (origanum), six species of which are found in Palestine. Others with more probability think that it was the caper plant, the Capparis spinosa of Linnaeus. This plant grew in Egypt, in the desert of Sinai, and in Palestine. It was capable of producing a stem three or four feet in length (Matt. 27:48; Mark 15:36. Comp. John 19:29).
Hyssop
Hyssop is a small plant used for sprinkling. The law of Moses names it among the things taken for cleansing, alongside cedar wood and scarlet, and dipped in blood and running water, whether for a person healed of leprosy or for a house. David reached for the same picture in his prayer of sorrow: “Purge me with hyssop, and I shall be clean: wash me, and I shall be whiter than snow.” He is asking for forgiveness, not for a ritual. If you want to see the ceremony itself, Leviticus 14 describes it step by step, and Psalm 51 shows what it came to mean in prayer.
5 verses
Leviticus
Then shall the priest command to take for him that is to be cleansed two birds alive and clean, and cedar wood, and scarlet, and hyssop:
As for the living bird, he shall take it, and the cedar wood, and the scarlet, and the hyssop, and shall dip them and the living bird in the blood of the bird that was killed over the running water:
And he shall take the cedar wood, and the hyssop, and the scarlet, and the living bird, and dip them in the blood of the slain bird, and in the running water, and sprinkle the house seven times:
And he shall cleanse the house with the blood of the bird, and with the running water, and with the living bird, and with the cedar wood, and with the hyssop, and with the scarlet:
Psalms
Purge me with hyssop, and I shall be clean: wash me, and I shall be whiter than snow.
From Easton's Bible Dictionary
Matthew George Easton, 1897