A large and populous city on the Thermaic bay. It was the capital of one of the four Roman districts of Macedonia, and was ruled by a praetor. It was named after Thessalonica, the wife of Cassander, who built the city. She was so called by her father, Philip, because he first heard of her birth on the day of his gaining a victory over the Thessalians. On his second missionary journey, Paul preached in the synagogue here, the chief synagogue of the Jews in that part of Macedonia, and laid the foundations of a church (Acts 17:1-4; 1 Thes. 1:9). The violence of the Jews drove him from the city, when he fled to Berea (Acts 17:5-10). The “rulers of the city” before whom the Jews “drew Jason,” with whom Paul and Silas lodged, are in the original called politarchai, an unusual word, which was found, however, inscribed on an arch in Thessalonica. This discovery confirms the accuracy of the historian. Paul visited the church here on a subsequent occasion (20:1-3). This city long retained its importance. It is the most important town of European Turkey, under the name of Saloniki, with a mixed population of about 85,000.
Thessalonica
Paul and Silas reached Thessalonica after passing through Amphipolis and Apollonia, and there they found a synagogue of the Jews. The city appears in Acts, where its people are called Thessalonians, and Aristarchus and Secundus travel with Paul from there. Two letters in the New Testament are addressed to the church of the Thessalonians, which Paul greets with “Grace be unto you, and peace.” Near the end of his life he also writes that Demas had left him and gone to Thessalonica. Acts 17 tells how the church began, and 1 Thessalonians 1 shows how Paul remembered it.
4 verses
Acts
Now when they had passed through Amphipolis and Apollonia, they came to Thessalonica, where was a synagogue of the Jews:
And there accompanied him into Asia Sopater of Berea; and of the Thessalonians, Aristarchus and Secundus; and Gaius of Derbe, and Timotheus; and of Asia, Tychicus and Trophimus.
1 Thessalonians
Paul, and Silvanus, and Timotheus, unto the church of the Thessalonians which is in God the Father and in the Lord Jesus Christ: Grace be unto you, and peace, from God our Father, and the Lord Jesus Christ.
2 Timothy
For Demas hath forsaken me, having loved this present world, and is departed unto Thessalonica; Crescens to Galatia, Titus unto Dalmatia.
From Easton's Bible Dictionary
Matthew George Easton, 1897